logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12286465 B1

PDFFull Text
Date of Patent:
Apr. 29, 2025

Filed:

May. 27, 2021

Chimeric antigen receptor with a spacer comprising c2-set ig-like domains

Applicant:

Miltenyi Biotec B.v. & Co. KG, Bergisch Gladbach, DE;

Inventors:

Rita Pfeifer, Cologne, DE;

Daniel Schäfer, Cologne, DE;

Ian Johnston, Rosrath, DE;

Assignee:

Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, DE;

Attorneys:

Christian Biervert, Esq.

Fish & Richardson P.C.

Primary Examiner:

Julie Wu

Assistant Examiner:

Bryan William Heck

Int. Cl.
CPC ...
C07K 14/705 (2005.12); A61K 40/11 (2024.12); A61K 40/31 (2024.12); A61K 40/42 (2024.12); C07K 14/47 (2005.12); C07K 16/28 (2005.12); A61K 38/00 (2005.12);
U.S. Cl.
CPC ...
C07K 14/705 (2012.12); A61K 40/11 (2024.12); A61K 40/31 (2024.12); A61K 40/4202 (2024.12); A61K 40/4221 (2024.12); A61K 40/4266 (2024.12); C07K 16/28 (2012.12); A61K 38/00 (2012.12); A61K 2239/38 (2023.04); A61K 2239/48 (2023.04); A61K 2239/54 (2023.04); C07K 14/4726 (2012.12); C07K 2317/622 (2012.12); C07K 2319/02 (2012.12); C07K 2319/03 (2012.12); C07K 2319/30 (2012.12);
Abstract

Provided herein are chimeric antigen receptors (CARs) that include a) an antigen binding domain specific for an antigen, b) a spacer, c) a transmembrane domain, and d) an intracellular signaling domain, wherein the spacer consists oforC-set Ig-like domain(s) e.g., C-set Ig-like domains of the sialic acid binding Ig-like lectin (Siglec) family. Also provided herein are compositions including a) an immune cell expressing a CAR, wherein the CAR is specific for a tag and b) a tagged polypeptide.

Find Patent Forward Citations

Quick Actions:

Pfeifer, Rita. (2025). Chimeric antigen receptor with a spacer comprising c2-set ig-like domains (U.S. Patent No. 12286465). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12286465

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…