The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2025
Filed:
Feb. 27, 2019
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
University of Florida Research Foundation, Incorporated, Gainsville, NC (US);
Aravind Asokan, Chapel Hill, NC (US);
Patrick Havlik, Carrboro, NC (US);
Mavis Agbandje-McKenna, Gainesville, FL (US);
James K. Smith, Gainesville, FL (US);
Mario Mietzsch, Gainesville, FL (US);
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
University of Florida Research Foundation, Incorporated, Gainsville, FL (US);
Abstract
The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo. This disclosure also relates to recombinant adeno associated virus (rAAV) capsid proteins comprising one or more amino acid substitutions in the 5-fold region of the rAAV capsid that result in decreased reactivity to neutralizing antibodies, and their use as gene delivery vehicles.