The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2025
Filed:
Nov. 29, 2023
Danisco Us Inc., Palo Alto, CA (US);
Dennis De Lange, Leiden, NL;
Marc Anton Bernhard Kolkman, Oegstgeest, NL;
Frank Wouter Koopman, Utrecht, NL;
Chris Leeflang, Twisk, NL;
DANISCO US INC., Palo Alto, CA (US);
Abstract
The instant disclosure is generally related to compositions and methods for obtaining and constructinghost cells (e.g., protein production host cells, cell factories) having increased protein production capabilities. Certain embodiments of the disclosure are directed to efficient genetic modifications ofcells and the subsequent selection of suchcells having increased protein production capabilities. Certain other embodiments of the disclosure are generally related to methods and compositions for producing/obtaining auxotrophiccells, wherein certain other embodiments of the disclosure are directed to methods and compositions for restoring prototrophy in auxotrophiccells, and expressing genes of interest (GOIs) in such restored prototrophycells.