The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2025

Filed:

Jun. 09, 2019
Applicants:

Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Samira Kiani, Scottsdale, AZ (US);

Mo R Ebrahimkhani, Scottsdale, AZ (US);

Jeremy Velazquez, Pittsburgh, PA (US);

Ryan LeGraw, Pittsburgh, PA (US);

Patrick Cahan, Baltimore, MD (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2009.12); A61K 35/407 (2014.12); C12N 15/113 (2009.12); C12N 15/86 (2005.12); C12N 15/90 (2005.12); G01N 33/50 (2005.12);
U.S. Cl.
CPC ...
C12N 5/0671 (2012.12); A61K 35/407 (2012.12); C12N 15/86 (2012.12); C12N 15/907 (2012.12); G01N 33/5014 (2012.12); G01N 33/5067 (2012.12); G01N 33/5088 (2012.12); C12N 2310/20 (2017.04); C12N 2501/15 (2012.12); C12N 2501/727 (2012.12); C12N 2506/45 (2012.12); C12N 2740/15043 (2012.12); C12N 2800/80 (2012.12);
Abstract

The present disclosure relates to synthetic liver organoids and methods of using such synthetic liver organoids for various applications including drug discovery and modeling human liver development. In particular, provided herein are methods of producing and using synthetic mature liver organoids comprising mature, functional cells found in the human liver.


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