The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2025
Filed:
Sep. 29, 2021
The Johns Hopkins University, Baltimore, MD (US);
Reid E. Messersmith, Severna Park, MD (US);
Scott A. Shuler, Baltimore, MD (US);
Mairead E. Bartlett, Takoma Park, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
A bifunctional linker of Formula 1 wherein in Formula I, at least one of Rto Ris —COORand Ris —C-Calkyl(C-Calkynyl) or —C-Calkyl-C-Calkenyl(C-Calkynyl), preferably a terminal alkynyl. The bifunctional linker is used in a cycloaddition to tether two entities, for example a protein or antibody, and an active agent, to form a bisconjugate. The bifunctional linker also be used to form a conjugate, followed by cycloaddition in the presence of a comonomer composition to form a bisconjugate including a protein or antibody linked to an adhesive polymer network. Catalysis can be provided by a copper-containing paint on a surface to adhere the bisconjugate to the surface. Methods of synthesis and use of the bisconjugates imaging, diagnostic, and therapeutic applications are also described.