The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2025
Filed:
Mar. 21, 2024
Generation Bio Co., Cambridge, MA (US);
Matthew G. Stanton, Cambridge, MA (US);
Birte Nolting, Cambridge, MA (US);
Andrew Milstead, Cambridge, MA (US);
Generation Bio Co., Cambridge, MA (US);
Abstract
Provided herein are lipids having the Formula I or Formula Ia: and pharmaceutically acceptable salts thereof, wherein R', R, R, R, R, R, R, R, X, X, and n are as defined herein for Formula I and Formula Ia, respectively. Also provided herein are lipid nanoparticle (LNP) compositions comprising lipid having the Formula I or Ia and a capsid-free, non-viral vector (e.g., ceDNA). In one aspect of any of the aspects or embodiments herein, these LNPs can be used to deliver a capsid-free, non-viral DNA vector to a target site of interest (e.g., cell, tissue, organ, and the like).