The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2025
Filed:
Dec. 31, 2018
Amgen Inc., Thousand Oaks, CA (US);
Amgen Research (Munich) Gmbh, Munich, DE;
Tobias Raum, Munich, DE;
Tara Arvedson, Thousand Oaks, CA (US);
Julie Bailis, Thousand Oaks, CA (US);
Christoph Dahlhoff, Munich, DE;
Sandra Ross, Thousand Oaks, CA (US);
Irwin Chen, Thousand Oaks, CA (US);
Claudia Blümel, Munich, DE;
Elisabeth Nahrwold, Munich, DE;
Jochen Pendzialek, Munich, DE;
Joachim Wahl, Munich, DE;
AMGEN INC., Thousand Oaks, CA (US);
AMGEN RESEARCH (MUNICH) GMBH, Munich, DE;
Abstract
The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and theCD3ε chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.