The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2025
Filed:
Jul. 14, 2022
Applicant:
Integrated Micro-chromatography Systems, Inc., Irmo, SC (US);
Inventors:
Caleb Reece Schlachter, Irmo, SC (US);
John Tomashek, Columbia, SC (US);
Lim Andrew Lee, Columbia, SC (US);
Assignee:
INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC., Irmo, SC (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/24 (2006.01); C12N 9/42 (2006.01); C12N 15/70 (2006.01); C12P 19/14 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2402 (2013.01); C07K 2319/00 (2013.01); C12N 9/2445 (2013.01); C12N 15/70 (2013.01); C12P 19/14 (2013.01); C12Y 302/01031 (2013.01);
Abstract
Chimeric and other variant β-glucuronidase enzymes with enhanced properties as compared to unmodified enzyme are provided. The enzymes of the invention advantageously exhibit enhanced enzymatic activity, enhanced substrate range, enhanced pH range, enhanced temperature range and/or enhanced enzyme stability. Methods of using the variant enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided.