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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12252719 B1

PDFFull Text
Date of Patent:
Mar. 18, 2025

Filed:

Jul. 14, 2022

Chimeric and other variant β-glucuronidase enzymes with enhanced properties

Applicant:

Integrated Micro-chromatography Systems, Inc., Irmo, SC (US);

Inventors:

Caleb Reece Schlachter, Irmo, SC (US);

John Tomashek, Columbia, SC (US);

Lim Andrew Lee, Columbia, SC (US);

Assignee:

INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC., Irmo, SC (US);

Attorneys:

Nelson Mullins Riley & Scarborough LLP

Jill Gorny Sloper, Esq.

Primary Examiner:

Soren Harward

Assistant Examiner:

Naghmeh Nina Moazzami

Int. Cl.
CPC ...
C12N 9/24 (2006.01); C12N 9/42 (2006.01); C12N 15/70 (2006.01); C12P 19/14 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2402 (2013.01); C07K 2319/00 (2013.01); C12N 9/2445 (2013.01); C12N 15/70 (2013.01); C12P 19/14 (2013.01); C12Y 302/01031 (2013.01);
Abstract

Chimeric and other variant β-glucuronidase enzymes with enhanced properties as compared to unmodified enzyme are provided. The enzymes of the invention advantageously exhibit enhanced enzymatic activity, enhanced substrate range, enhanced pH range, enhanced temperature range and/or enhanced enzyme stability. Methods of using the variant enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided.

Find Patent Forward Citations

Schlachter, Caleb. (2025). Chimeric and other variant β-glucuronidase enzymes with enhanced properties (U.S. Patent No. 12252719). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12252719

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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