The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2025
Filed:
Aug. 06, 2021
Decibel Therapeutics, Inc., Boston, MA (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Joseph Burns, Newton, MA (US);
Kathryn Ellis, Arlington, MA (US);
Adam Palermo, Somerville, MA (US);
Martin Schwander, Auburndale, MA (US);
Jonathon Whitton, Cambridge, MA (US);
Leah Sabin, Goldens Bridge, NY (US);
Christos Kyratsous, Irvington, NY (US);
Meghan Drummond Samuelson, Katonah, NY (US);
Decibel Therapeutics, Inc., Boston, MA (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
The disclosure provides polynucleotides containing regions of the Myosin 15 (Myo15) promoter, as well as vectors containing the same, that can be used to promote expression of a transgene specifically in hair cells. The polynucleotides described herein may be operably linked to a transgene, such as a transgene encoding a therapeutic protein, so as to promote hair cell-specific expression of the transgene. The polynucleotides described herein may be operably linked to a therapeutic transgene and used for the treatment of subjects having or at risk of developing hearing loss or vestibular dysfunction.