The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 11, 2025

Filed:

Oct. 15, 2019
Applicant:

Intervet Inc., Madison, NJ (US);

Inventors:

Marco Groot, Beugen, NL;

Theodorus Jansen, Venray, NL;

Assignee:

Intervet Inc., Rahway, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/107 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 47/14 (2017.01); A61P 31/04 (2006.01);
U.S. Cl.
CPC ...
A61K 9/107 (2013.01); A61K 39/00 (2013.01); A61K 39/12 (2013.01); A61K 47/14 (2013.01); A61P 31/04 (2018.01); A61K 2039/521 (2013.01); A61K 2039/552 (2013.01);
Abstract

The present invention is based on the discovery of new and advantageous properties of a class of known polymeric emulsifiers. The emulsifier class was found to be resistant to degradation by crude bacterial antigen preparations, which degradation caused emulsion instability when using prior art emulsifiers. This allows the formulation of safe, stable, and effective vaccines based on these emulsions of oil and water comprising such bacterial antigens. The polymeric emulsifier is a block copolymer having a general formula A-B-A in which component B is the divalent residue of a water-soluble polyalkylene glycol and component A is the residue of an oil-soluble complex monocarboxylic acid. Preferred emulsifier is a PEG-30-di-(polyhydroxystearate).


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