The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2025
Filed:
Feb. 03, 2021
Syntis Bio, Inc., Boston, MA (US);
Joyce Liu, Fremont, CA (US);
Leann Quertinmont Teadt, Redwood City, CA (US);
Nikki Dellas, San Carlos, CA (US);
Stephan Jenne, Foster City, CA (US);
Faye Loan Du, San Jose, CA (US);
Kristen Jean Vallieu, Union City, CA (US);
Kerryn McCluskie, Pacifica, CA (US);
SYNTIS BIO, INC., Boston, MA (US);
Abstract
The present invention provides engineered leucine decarboxylase (LDC) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered leucine decarboxylase (LDC) polypeptides. In some embodiments, the engineered LDC polypeptides are optimized to provide enhanced catalytic activity, as well as reduced sensitivity to proteolysis, and/or increased tolerance to low pH environments. In some embodiments, the engineered LDC polypeptides are optimized to provide improved storage stability. The present invention also provides methods for the use of the compositions comprising the engineered LDC polypeptides for therapeutic and industrial purposes.