The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2025
Filed:
Aug. 16, 2019
Applicant:
Institute of Process Engineering, Chinese Academy of Sciences, Beijing, CN;
Inventors:
Guanghui Ma, Beijing, CN;
Wei Wei, Beijing, CN;
Shuang Wang, Beijing, CN;
Shuang Qing, Beijing, CN;
Jianghua Wang, Beijing, CN;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 35/15 (2015.01); A61K 35/17 (2015.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); C12N 5/0786 (2010.01); C12N 5/16 (2006.01);
U.S. Cl.
CPC ...
C12N 5/163 (2013.01); A61K 35/15 (2013.01); A61K 35/17 (2013.01); A61K 39/0011 (2013.01); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C12N 5/0645 (2013.01); A61K 2039/5154 (2013.01); A61K 2039/572 (2013.01);
Abstract
Provided is an exosome, which is secreted by a hybrid cell formed by antigen-presenting cells phagocytosing the cell nuclei of tumor cells. Using the strategy of macrophages phagocytosing the cell nuclei of tumor cells achieves endogenous expression of tumor antigens on macrophages, and the exosome prepared has good capabilities of targeting to lymph nodes and tumors dually.