The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Oct. 18, 2019
The University of Chicago, Chicago, IL (US);
Nationwide Children's Hospital, Columbus, OH (US);
The Ohio State University, Columbus, OH (US);
Jianrong Li, Dublin, OH (US);
Mark E. Peeples, Bexley, OH (US);
Chuan He, Chicago, IL (US);
Stefan Niewiesk, Dublin, OH (US);
Mijia Lu, Columbus, OH (US);
Miaoge Xue, Columbus, OH (US);
Zijie Zhang, Chicago, IL (US);
Boxuan Zhao, Palo Alto, CA (US);
The University of Chicago, Chicago, IL (US);
Nationwide Children's Hospital, Columbus, OH (US);
The Ohio State University, Columbus, OH (US);
Abstract
The current disclosure relates to methods, compositions and kits for detecting modified adenosine in a target RNA molecule. Aspects relate to a method for detecting modified adenosine in a target ribonucleic acid (RNA) comprising contacting the target RNA with an adenosine deaminase enzyme (adenosine deaminase, RNA-specific) to generate a target RNA with deaminated adenosines and sequencing the target RNA with deaminated adenosines; wherein the modified adenosine is detected when the nucleotide sequence includes adenosine within a m6A motif.