The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
May. 23, 2019
Chengdu Olymvax Biopharmaceuticals Inc., Chengdu, CN;
Hengliang Wang, Beijing, CN;
Li Zhu, Beijing, CN;
Chao Pan, Beijing, CN;
Zhicheng Liu, Beijing, CN;
Xin Li, Beijing, CN;
Jun Wu, Beijing, CN;
Peng Sun, Beijing, CN;
Ming Zeng, Beijing, CN;
Bin Wang, Beijing, CN;
Xiankai Liu, Beijing, CN;
Dongshu Wang, Beijing, CN;
Erling Feng, Beijing, CN;
CHENGDU OLYMVAX BIOPHARMACEUTICALS INC., Chengdu, CN;
Abstract
The present invention discloses aimmunogenic protein and its composition and application. This invention provides a protein, comprising 39 amino acids of the N-terminal α-helix part of the Ata protein transport functional domain ofand an adjuvant protein; amino acid sequence of said 39 amino acids of the N-terminal α-helix part of the Ata protein transport functional domain ofis shown as the 127-165amino acid residues of SEQ ID NO:2. In present invention the 39 amino acids of the N-terminal α-helix part of surface protein Ata (trimeric autotransporter) of, was took to fuse with CTB, and express in BL21. The protein was purified by a nickel column, and used to intraperitoneally immunize mouses by 2.5 μg/mouse. Its immunogenicity and immunoprotection was verified through the animal experiments, which proves it has a good effect of anti-infection of