The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Oct. 28, 2021
Applicant:
Kalivir Immunotherapeutics, Inc., Pittsburgh, PA (US);
Inventors:
Stephen H. Thorne, Pittsburgh, PA (US);
Daniel J. Byrd, Pittsburgh, PA (US);
Mingrui Zhang, Pittsburgh, PA (US);
Assignee:
KaliVir Immunotherapeutics, Inc., Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/768 (2015.01); A61P 35/00 (2006.01); C07K 14/715 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); A61P 35/00 (2018.01); C07K 14/7158 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12Y 302/01035 (2013.01);
Abstract
Described herein are modified oncolytic viruses that can contain modifications in the viral genome and exogenous nucleic acids coding for proteins. The modified oncolytic virus can be utilized as a platform vector for systemic delivery. Further described herein are oncolytic viruses having an exogenous nucleic acid that codes for a protein or a functional variant thereof that enhances degradation of an extracellular matrix (ECM) associated with a tumor, wherein the protein is a membrane associated protein.