The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2025
Filed:
Sep. 20, 2023
The United States of America,as Represented BY the Secretary,department of Health and Human Services, Bethesda, MD (US);
Ira H. Pastan, Chevy Chase, MD (US);
Junxia Wei, Rockville, MD (US);
Masanori Onda, Germantown, MD (US);
Tapan Bera, Frederick, MD (US);
Mitchell Ho, Urbana, MD (US);
Abstract
Disclosed is a molecule comprising: (a) a first domain, which comprises a targeting moiety; (b) a second domain, which comprises an albumin binding domain (ABD), (c) a third domain, which comprises a furin cleavage sequence ('FCS'), which FCS is cleavable by furin; and (d) a fourth domain, which comprises an optionally substituted Domain III fromexotoxin A (“PE”). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of producing the molecule, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.