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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12209091 B1

PDFFull Text
Date of Patent:
Jan. 28, 2025

Filed:

Nov. 25, 2020

Isoindolinone derivatives as selective allosteric inhibitors of egfr mutant cancers

Applicant:

Hoffmann-la Roche Inc., Little Falls, NJ (US);

Inventors:

Martin Duplessis, Somerville, MA (US);

Annick Goergler, Colmar, FR;

Georg Jaeschke, Basel, CH;

Buelent Kocer, Maulburg, DE;

Bernd Kuhn, Reinach BL, CH;

Kiel Lazarski, Boston, MA (US);

Yanke Liang, Belmont, MA (US);

Yvonne Alice Nagel, Basel, CH;

Ulrike Obst Sander, Reinach BL, CH;

Antonio Ricci, Biel-Benken, CH;

Daniel Rueher, Raedersdorf, FR;

Sandra Steiner, Sursee, CH;

Assignee:

Hoffmann-La Roche Inc., Little Falls, NJ (US);

Attorney:

Knowles Intellectual Property Strategies, LLC

Primary Examiner:

Kortney L Klinkel

Assistant Examiner:

Padmaja S Rao

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 9/00 (2006.01); A61K 9/02 (2006.01); A61K 9/08 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 47/02 (2006.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); A61K 47/34 (2017.01); A61K 47/38 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 9/0019 (2013.01); A61K 9/02 (2013.01); A61K 9/08 (2013.01); A61K 9/2009 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 9/4825 (2013.01); A61K 9/485 (2013.01); A61K 9/4858 (2013.01); A61K 9/4866 (2013.01); A61K 9/4875 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); A61K 47/34 (2013.01); A61K 47/38 (2013.01);
Abstract

The present invention provides compounds which are selective allosteric inhibitors of T790M/L858R, T790M/L858R/C797S, L858R, L858R/C797S containing EGFR mutants, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.

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