The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2025
Filed:
Jan. 05, 2018
Applicant:
Protalix Ltd., Carmiel, IL;
Inventors:
Einat Almon, Timrat, IL;
Raul Chertkoff, Adi, IL;
Sari Alon, Kibbutz Moran, IL;
Yoseph Shaaltiel, Timrat, IL;
Assignee:
Protalix Ltd., Carmiel, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/47 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 38/47 (2013.01); C12N 15/85 (2013.01); C12Y 302/01022 (2013.01);
Abstract
Methods of treating Fabry disease via administration of stabilized plant recombinant human alpha galactosidase protein comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety, and unit dosages of protein are disclosed herein. The disclosed protocols are safe, have greater than 2 week intervals between administrations and exhibit important improvement in patient's disease parameters, in terms of reduced Gb3 accumulation, pain and GI parameters, kidney and cardiac stabilization in the clinical setting.