The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2024
Filed:
Jan. 10, 2019
Applicant:
Translate Bio Ma, Inc., Lexington, MA (US);
Inventors:
Balkrishen Bhat, Carlsbad, CA (US);
Jia Tay, Acton, MA (US);
Saswata Karmakar, Acton, MA (US);
Nelson Chau, Needham, MA (US);
Assignee:
Translate Bio MA, Inc., Lexington, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); A61K 38/45 (2006.01); A61K 47/54 (2017.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 38/45 (2013.01); A61K 47/549 (2017.08); C12N 15/113 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/3519 (2013.01); C12Y 201/03003 (2013.01);
Abstract
Provided herein are compositions and methods for facilitating or enhancing delivery of nucleic acids, such as synthetic mRNAs, into cells or tissues. Such compositions and methods may include use of a targeting moiety-conjugated, such as an N-acetylgalactosamine (GalNAc)-conjugated, oligonucleotide to facilitate or enhance delivery.