The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2024
Filed:
Oct. 02, 2020
Applicant:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Muthiah Manoharan, Cambridge, MA (US);
Jayaprakash K. Nair, Cambridge, MA (US);
Pachamuthu Kandasamy, Cambridge, MA (US);
Shigeo Matsuda, Cambridge, MA (US);
Alexander V. Kelin, Cambridge, MA (US);
Muthusamy Jayaraman, Cambridge, MA (US);
Kallanthottathil G. Rajeev, Cambridge, MA (US);
Assignee:
ALNYLAM PHARMACEUTICALS, INC., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); A61K 47/54 (2017.01); C07H 21/00 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 47/549 (2017.08); C07H 21/00 (2013.01); C12N 15/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/351 (2013.01); C12N 2320/30 (2013.01); C12N 2320/32 (2013.01); C12N 2330/30 (2013.01);
Abstract
The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.