The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2024
Filed:
Sep. 18, 2020
Applicant:
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Inventors:
Assignee:
CHUGAI SEIYAKU KABUSHIKI KAISHA, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/10 (2006.01); C12N 9/00 (2006.01); C12N 9/22 (2006.01); C12N 15/09 (2006.01); C12N 15/70 (2006.01); C12P 19/34 (2006.01); C12P 21/00 (2006.01); C12P 21/02 (2006.01);
U.S. Cl.
CPC ...
C12N 15/70 (2013.01); C12N 5/10 (2013.01); C12N 9/00 (2013.01); C12N 9/22 (2013.01); C12N 9/93 (2013.01); C12N 15/09 (2013.01); C12P 19/34 (2013.01); C12P 21/00 (2013.01); C12P 21/02 (2013.01);
Abstract
The present invention provides modified aminoacyl-tRNA synthetases (ARSs) having increased reactivity with N-methyl amino acids compared to natural aminoacyl-tRNA synthetases. The modified aminoacyl-tRNA synthetases according to the present invention can aminoacylate tRNAs with their corresponding N-methyl-substituted amino acids such as N-methyl-phenylalanine, N-methyl-valine, N-methyl-serine, N-methyl-threonine, N-methyl-tryptophan and N-methyl-leucine more efficiently than natural aminoacyl-tRNA synthetases. The present invention enables a more efficient production of polypeptides containing N-methyl amino acids.