The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2024
Filed:
Jun. 09, 2022
Applicant:
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Inventors:
Patrick McHugh, Pipersville, PA (US);
Michael Albert Winters, Doylestown, PA (US);
Janelle Konietzko, Lansdale, PA (US);
Assignee:
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/54 (2017.01); A61K 47/62 (2017.01); C07H 1/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/549 (2017.08); A61K 47/62 (2017.08); C07H 1/00 (2013.01);
Abstract
The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides fromto a carrier protein. These process are serotype specific and include acid hydrolysis, addition of sodium chloride to the reductive amination reaction, and addition of sucrose to dissolve polysaccharides. Polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccines.