The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 2024
Filed:
Apr. 25, 2019
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Patrick Leonard Ahl, West Point, PA (US);
Akhilesh Bhambhani, Doylestown, PA (US);
Christopher Jon Farrell, Wayne, PA (US);
Patrick McHugh, Pipersville, PA (US);
Morrisa C. Jones, Upper Darby, PA (US);
Daniel D. Roth, Coopersburg, PA (US);
Jessica R. Sinacola, Collegeville, PA (US);
Justin Stanbro, Sellersville, PA (US);
Matthew P. Watson, Ottsville, PA (US);
Emily Wen, Harleysville, PA (US);
Michael A. Winters, Doylestown, PA (US);
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized in the form of lyospheres of carrier protein and lyospheres of the one or more polysaccharides. A predetermined amount of carrier protein lyospheres and activated polysaccharide lyospheres are mixed together and the mixture reconstituted in an organic solvent to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.