The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2024
Filed:
Jun. 22, 2022
Ctcells, Inc., Daegu, KR;
Kka Bi Son, Daejeon, KR;
Jeong Hyeon Bak, Daejeon, KR;
Dae Hee Lee, Daejeon, KR;
Se Il Jang, Daejeon, KR;
Jung Min Lee, Daegu, KR;
Ji Hye Yoon, Daejeon, KR;
Jong Gwan Jeong, Daejeon, KR;
CTCELLS, INC., Daegu, KR;
Abstract
The present invention relates to a cytokine trimer domain in which a first monomer and a second monomer linked by linker (dimer) and a third monomer are coupled by a knob-into-hole and a novel type of fusion protein in which antibody and cytokine trimer domains are linked (receptor-antibody conjugated (cell) engager, RACE) prepared by replacing a constant region (Fc) of an antibody with the cytokine trimer domain, and RACE according to the present invention exhibits superior binding ability to the target receptor than the parent antibody as well as excellent simultaneous binding ability to the antigen and the target receptor, which can be usefully utilized as a bispecific pharmaceutical composition.