The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2024
Filed:
Nov. 02, 2021
Abzyme Therapeutics Llc, Pottstown, PA (US);
Hiep Tran, West Chester, PA (US);
Carla Campbell, Royersford, PA (US);
Byung Lee, Watertown, MA (US);
Fouad Moussa, Allentown, PA (US);
Andrew Phillips, Pottstown, PA (US);
Rajesh Singh, Malvern, PA (US);
Laura DeCristofano, Phoenixville, PA (US);
Abzyme Therapeutics LLC, Pottstown, PA (US);
Abstract
The invention relates to new anti-hCD3 antibodies that, in contrast to prior art anti-CD3 antibodies, bind specifically to human CD3 at acidic pH, but do not significantly bind to human CD3 at neutral or physiological pH, methods to produce these antibodies and therapeutic uses of these antibodies. These antibodies are able to activate T cells at acidic pH while having significantly reduced activity at neutral or physiological pH.