The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2024
Filed:
Nov. 06, 2023
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Marine Prissette, Brooklyn, NY (US);
Matthew Koss, Pleasantville, NY (US);
Mathieu Desclaux, Brooklyn, NY (US);
John McWhirter, Hastings-on-Hudson, NY (US);
Arijit Bhowmick, Astoria, NY (US);
David Frendewey, New York, NY (US);
Brian Zambrowicz, Sleepy Hollow, NY (US);
Claudia Racioppi, New York, NY (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
BANF1, PPP2CA, and ANKLE2 were identified as genes that promote tau aggregation when disrupted. Improved tauopathy models such as cells, tissues, or animals having mutations in or inhibition of expression of BANF1 and/or PPP2CA and/or ANKLE2 are provided. Methods of using such improved tauopathy models for assessing therapeutic candidates for the treatment of a tauopathy, methods of making the improved tauopathy models, and methods of accelerating or exacerbating tau aggregation in a tauopathy model are also provided.