The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2024
Filed:
Jul. 11, 2019
Applicant:
Hedgehog, Inc., Seoul, KR;
Inventors:
Sang Cheul Oh, Seoul, KR;
Dae-Hee Lee, Gyeonggi-do, KR;
Assignee:
HEDGEHOG, INC., Seoul, KR;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 31/7088 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 31/7088 (2013.01); A61P 35/00 (2018.01); C07K 14/705 (2013.01); G01N 33/574 (2013.01);
Abstract
The present invention identifies the influence of the TGFβ/Smad3/SMO molecular mechanism in cancer cells and elucidates that a high expression level of SMO is associated with the overall survival rate of cancer patients, demonstrating that SMO is a potential prognostic marker for cancer. The present invention relates to a specific epitope of SMO as an antigen and an antibody or a fragment thereof recognizing and binding specifically to the epitope. Therefore, the antibody of the present invention is expected to be useful as a therapeutic agent for SMO-related cancers.