The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 17, 2024

Filed:

Dec. 01, 2023
Applicants:

Jiangnan University, Wuxi, CN;

Standard Foods (China) Co., Ltd, Suzhou, CN;

Le Bonta Wellness Co., Ltd, Shanghai, CN;

Inventors:

Peng Zhou, Wuxi, CN;

Changshu Liu, Suzhou, CN;

Yaowei Liu, Wuxi, CN;

Tao Yang, Wuxi, CN;

Yan Zheng, Wuxi, CN;

Jianguo Liu, Suzhou, CN;

Kexin Li, Shanghai, CN;

Shuyan Lu, Shanghai, CN;

Assignees:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 9/107 (2006.01); A61K 31/7028 (2006.01); A61K 47/26 (2006.01); A61K 47/42 (2017.01); A61K 47/44 (2017.01);
U.S. Cl.
CPC ...
A61K 9/1075 (2013.01); A61K 31/7028 (2013.01); A61K 47/26 (2013.01); A61K 47/42 (2013.01); A61K 47/44 (2013.01);
Abstract

The present disclosure relates to a method to improve the encapsulation efficiency and physicochemical stability of ginsenosides Rg3 and CK nano-emulsion, belonging to the field of functional emulsions. The method to improve the encapsulation efficiency and physicochemical stability of ginsenosides Rg3 and CK nano-emulsion, includes the following steps: (1) WPI, Tween 80 and water were mixed evenly according to the amount ratio of 0.5 g:0.5-0.7 g:50 mL to obtain the aqueous phase; (2) Mixing a saponin extract containing the minor ginsenosides Rg3 and CK with edible oil evenly to obtain the oil phase; (3) Mixing the aqueous phase with the oil phase, carrying out shearing dispersion to obtain coarse emulsion, and then allowing the coarse emulsion to be subjected to microfluidization homogenization to obtain an oil-in-water nano-emulsion containing the minor ginsenosides Rg3 and CK. The nano-emulsion of the disclosure has a high encapsulation efficiency of Rg3 and CK, good physicochemical stability during storage, freeze-thaw cycles, heating, and other industrial treatments, which could be used to improve the bioavailability of minor ginsenoside Rg3 and CK.


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