The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2024
Filed:
May. 15, 2019
Applicant:
Spark Therapeutics, Inc., Philadelphia, PA (US);
Inventors:
Assignee:
SPARK THERAPEUTICS, INC., Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/26 (2006.01); A61K 48/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2408 (2013.01); A61K 48/005 (2013.01); C12N 15/86 (2013.01); C12Y 302/0102 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14152 (2013.01); C12N 2800/22 (2013.01); C12N 2830/001 (2013.01); C12N 2830/50 (2013.01);
Abstract
The invention provides nucleic acids encoding acid α-glucosidase (GAA). In certain embodiments, nucleic acids have greater than about 86% sequence identity to a sequence selected from the group consisting of any of the sequences set forth as SEQ ID NOs:1-5. In certain embodiments, nucleic acids encoding acid α-glucosidase (GAA) contain less than 127 CpG dinucleotides. Expression cassettes, vectors, cells and cell lines and methods of using such nucleic acids encoding acid α-glucosidase (GAA) are also provided.