The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2024
Filed:
Dec. 20, 2021
Clark Atlanta University, Inc., Atlanta, GA (US);
Georgia Tech Research Corporation, Atlanta, GA (US);
Shafiq A. Khan, Mableton, GA (US);
Silvia Caggia, Decatur, GA (US);
Adegboyega K. Oyelere, Marietta, GA (US);
Subhasish Tapadar, Atlanta, GA (US);
CLARK ATLANTA UNIVERSITY, INC., Atlanta, GA (US);
GEORGIA TECH RESEARCH CORPORATION, Atlanta, GA (US);
Abstract
The disclosure relates to novel compounds and methods of use of the compounds to maintain the Gα2 protein in its inactive GDP-bound state. The disclosure describes the knockdown or inhibition of Gα2 negatively regulated migration of breast and ovarian cancer cell lines. The novel compounds inhibit the migratory behavior of PC3, DU145 and E006AA prostate cancer cell lines. Specifically, the novel compounds block the activation of Gα2 in oxytocin-stimulated prostate cancer PC3 cells and inhibits the migratory capability of DU145 cells overexpressing constitutively active form of Gα2, under basal and EGF-stimulated conditions.