The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2024
Filed:
Oct. 26, 2022
Applicant:
Integrated Micro-chromatography Systems, Inc., Irmo, SC (US);
Inventors:
Lim Andrew Lee, Columbia, SC (US);
Caleb Reece Schlachter, Irmo, SC (US);
John Tomashek, Columbia, SC (US);
Assignee:
INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC., Irmo, SC (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/46 (2006.01); A61K 38/16 (2006.01); C07K 14/00 (2006.01); C12N 9/16 (2006.01);
U.S. Cl.
CPC ...
A61K 38/465 (2013.01); A61K 38/16 (2013.01); C07K 14/00 (2013.01); C12N 9/16 (2013.01); C12Y 301/06013 (2013.01);
Abstract
Mutatedsulfatase (PaS) enzymes with enhanced enzymatic activity as compared to the parental wild type enzyme are provided. The variant sulfatases of the invention advantageously allow for accurate analysis of bodily samples for the presence of drugs. Methods of using the mutated enzymes for hydrolysis of sulfate ester linkages are also provided, including with substrates such as opioids or steroids containing a sulfate ester linkage.