The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2024
Filed:
May. 06, 2021
Venus Medtech (Hangzhou), Inc., Zhejiang, CN;
Sichuan University, Chengdu, CN;
Yunbing Wang, Chengdu, CN;
Yang Lei, Chengdu, CN;
Gaocan Li, Chengdu, CN;
Li Yang, Chengdu, CN;
Hou-Sen Lim, Singapore, SG;
Dajun Kuang, Zhejiang, CN;
Jincheng Yu, Hangzhou, CN;
VENUS MEDTECH (HANGZHOU), INC., Hangzhou, CN;
Sichuan University, Chengdu, CN;
Abstract
A pre-loadable dried biological heart valve and a preparation method thereof. The preparation method includes: Step A: soaking a fresh animal pericardium in an aqueous solution of soluble elastin or glycosaminoglycan, and then subjecting the pericardium to a first cross-linking reaction in a mixed solution of carbodiimide or N-hydroxysuccinimide to allow the soluble elastin or glycosaminoglycan to bind to the pericardium via a chemical bond; and Step B: subjecting the pericardium after the first cross-linking to a second cross-linking reaction in an aqueous glutaraldehyde solution, and then drying the pericardium after the second cross-linking, to obtain the pre-loadable dried biological heart valve. The dried biological heart valve obtained by the above preparation method has good toughness, and is rapidly flattened out in a simulated folding and pressing test.