The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2024
Filed:
Apr. 18, 2018
Ramot AT Tel-aviv University Ltd., Tel-Aviv, IL;
Adi Barzel, Hod Hasharon, IL;
Iris Dotan, Tel-Aviv, IL;
Carmel Pundak-Mintz, Tel-Aviv, IL;
Daniel Nataf, Tel-Aviv, IL;
Miriam Fried, Tel-Aviv, IL;
Natalia Gritsenko, Tel-Aviv, IL;
Ramot at Tel-Aviv University Ltd., Tel-Aviv, IL;
Abstract
The present invention relates to methods for targeted insertion of at least one nucleic acid sequence/s of interest into a target genomic locus of a mammalian cell. More specifically, the methods of the invention are based on using nucleic acid cassettes comprising the nucleic acid sequence/s of interest and at least one recognition signal sequence (RSS), for insertion of the nucleic acid sequence of interest into the target genomic locus that is mediated by RAG-catalyzed recombination. The invention further provides cassettes, vectors and vehicles and cells comprising said cassettes, compositions and uses thereof in immunotherapy.