The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2024
Filed:
May. 31, 2017
Beihao Stem Cell and Regenerative Medicine Research Institute Co., Ltd., Guangdong, CN;
Hong Guan Ltd., Beijing, CN;
Hongkui Deng, Beijing, CN;
Xiang Li, Beijing, CN;
Defang Liu, Beijing, CN;
Yantao Ma, Beijing, CN;
Xiaomin Du, Beijing, CN;
BeiHao Stem Cell and Regenerative Medicine Research Institute Co., Ltd., Guangdong, CN;
HONG GUAN LTD., Beijing, CN;
Abstract
Provided are chemical inducers of lineage reprogramming (CiLR) which include glycogen synthase kinase inhibitors, TGFβ receptor inhibitors, cyclic AMP agonists or histone acetylators. Also provided is a method of inducing lineage reprograming in a partially or completely differentiated cell of a first type into a cell with characteristics of a second and different lineage. The method includes: contacting a cell with the CiLR for a sufficient period of time to result in reprograming the cell into a modified XEN-like cell which is subsequently programmed into a cell with characteristics of a second and different lineage.