The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2024
Filed:
Dec. 13, 2022
Applicant:
Kalivir Immunotherapeutics, Inc., Pittsburgh, PA (US);
Inventors:
Stephen Howard Thorne, Pittsburgh, PA (US);
Mingrui Zhang, Pittsburgh, PA (US);
Assignee:
KaliVir Immunotherapeutics, Inc., Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/768 (2015.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07K 14/065 (2006.01); C07K 14/47 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 14/065 (2013.01); C07K 14/4702 (2013.01); C12N 15/86 (2013.01);
Abstract
The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.