The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 11, 2024

Filed:

Oct. 07, 2021
Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

José Ignacio Andrés-Gil, Madrid, ES;

Guy Maurits R. Bormans, Rotselaar, BE;

Lieven Denis Herwig Declercq, Bierbeek, BE;

Katleen Fierens, Antwerp, BE;

Joseph Elisabeth Leenaerts, Rijkovorsel, BE;

Diederik Willem Elisabeth Moechars, Rotselaar, BE;

Frederik Jan Rita Rombouts, Wilrijk, BE;

Hartmuth Kolb, San Diego, CA (US);

Wei Zhang, San Diego, CA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); A61K 51/04 (2006.01); C07B 59/00 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 51/0455 (2013.01); C07B 59/002 (2013.01); A61K 2123/00 (2013.01);
Abstract

The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.


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