The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2024
Filed:
Apr. 30, 2021
Sp. cas12a mutants with enhanced cleavage activity at non-canonical tttt protospacer adjacent motifs
Applicant:
Integrated Dna Technologies, Inc., Coralville, IA (US);
Inventors:
Liyang Zhang, North Liberty, IA (US);
Christopher Anthony Vakulskas, North Liberty, IA (US);
Assignee:
INTEGRATED DNA TECHNOLOGIES, INC., Coralville, IA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01);
Abstract
Described herein are CAS12A mutants fromand methods for use thereof. These mutants have enhanced DNA cleavage activities at non-canonical TTTT protospacer adjacent motifs (PAM) compared to the wild-type enzyme.