The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 04, 2024

Filed:

May. 06, 2020
Applicant:

National Technology & Engineering Solutions of Sandia, Llc, Albuquerque, NM (US);

Inventors:

Brooke Nicole Harmon, Livermore, CA (US);

Yooli Kim Light, Pleasanton, CA (US);

Mary Bao Tran-Gyamfi, Pleasanton, CA (US);

Joseph S. Schoeniger, Oakland, CA (US);

Edwin A. Saada, Dublin, CA (US);

Kenneth L. Sale, Pleasanton, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/08 (2006.01); A61K 38/46 (2006.01); C07K 14/00 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); A61K 38/465 (2013.01); C07K 14/001 (2013.01); A61K 9/0053 (2013.01); C12N 2310/20 (2017.05); C12N 2310/3513 (2013.01); C12N 2310/3519 (2013.01); C12Y 301/00 (2013.01);
Abstract

Specific and broad-spectrum inhibitory peptides to CRISPR Cas9 variants (SpyCas9, SauCas9, and CjeCas9) are disclosed. A method of making and using these peptides with therapeutic CRISPR Cas9 (to improve desired targeting) or against harmful CRISPR Cas9 components (already active in a patient) is also disclosed. The peptides combined with a delivery system is also disclosed.


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