The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2024
Filed:
Jul. 13, 2018
Applicant:
Cedars-sinai Medical Center, Los Angeles, CA (US);
Inventors:
Alexander Laperle, North Hollywood, CA (US);
Clive Svendsen, Pacific Palisades, CA (US);
Assignee:
Cedars-Sinai Medical Center, Los Angeles, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/00 (2006.01); C03C 17/30 (2006.01); C03C 23/00 (2006.01); C12M 3/00 (2006.01);
U.S. Cl.
CPC ...
C12M 23/20 (2013.01); C03C 17/30 (2013.01); C03C 23/006 (2013.01); C12M 3/00 (2013.01);
Abstract
Described herein is functionalized glass allowing for robust attachment of extracellular matrix proteins (ECM) withstanding extended culturing periods. By first treating glass with a sulfur silane reagent, the treated glass can be activated via an amine-sulfur linker, after which ECM proteins are attached to the linker. The Inventors observed that this glass treatment combination (sulfur silane-linker-ECM) resisted degradation when compared to conventional surface coatings, such as poly-L-orthinine coated glass.