The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2024
Filed:
Dec. 17, 2018
Yangzhou Aoruite Pharmaceutical Co. Ltd., Jiangsu, CN;
Yangzhou Lianao Biomedical Co., Ltd., Jiangsu, CN;
Zhenpeng Yu, Jiangsu, CN;
Fei Xiao, Jiangsu, CN;
Guoping Wang, Jiangsu, CN;
Shuxian Qi, Jiangsu, CN;
He Gao, Jiangsu, CN;
YANGZHOU AORUITE PHARMACEUTICAL CO., LTD., Jiangsu, CN;
YANGZHOU LIANAO BIOMEDICAL CO., LTD., Jiangsu, CN;
Abstract
The invention discloses a method of preparing a high chiral purity lactam intermediate D comprising a step of reducing a compound C to lactam intermediate D in a solvent by hydrogenation reduction using a heavy metal catalyst and a chiral inducer. Brivaracetam can be prepared in a single step using the lactam intermediate D. The synthesis route is short, reaction conditions are mild, post-treatment is simple, reaction yield is high, chiral selectivity is good, and production cost is low. The conversion rate of the compound C in the reaction is 81%, and the DE value of the compound D is more than 99.0%, which is suitable for industrial production.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile