The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2024
Filed:
Oct. 19, 2018
Applicant:
Trianni, Inc., Wilmington, DE (US);
Inventors:
Matthias Wabl, San Francisco, CA (US);
Werner Mueller, Cologne, DE;
Peter Burrows, Birmingham, AL (US);
Gloria Esposito, Vienna, AT;
Bao Duong, Pacifica, CA (US);
Assignee:
TRIANNI, INC., Wilmington, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); A01K 67/027 (2006.01); A01K 67/0278 (2024.01); C07K 16/18 (2006.01); C12N 5/074 (2010.01); C12N 15/10 (2006.01); C12N 15/62 (2006.01); C40B 40/10 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8509 (2013.01); A01K 67/0278 (2013.01); C07K 16/18 (2013.01); C12N 5/0696 (2013.01); C12N 15/1072 (2013.01); C12N 15/62 (2013.01); C40B 40/10 (2013.01); A01K 2207/15 (2013.01); A01K 2217/054 (2013.01); A01K 2217/072 (2013.01); A01K 2227/105 (2013.01); A01K 2267/01 (2013.01); A01K 2267/03 (2013.01); C12N 2015/8518 (2013.01); C12N 2015/8527 (2013.01);
Abstract
The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.