The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2024
Filed:
May. 31, 2018
Arcturus Therapeutics, Inc., San Diego, CA (US);
Kiyoshi Tachikawa, San Diego, CA (US);
Carlos Gustavo Perez-Garcia, San Diego, CA (US);
Padmanabh Chivukula, San Diego, CA (US);
Hari Bhaskaran, San Diego, CA (US);
Sean Christopher Daugherty, Petaluma, CA (US);
Christian W. Cobaugh, Newton, MA (US);
Arcturus Therapeutics, Inc., San Diego, CA (US);
Abstract
This invention provides a range of translatable polynucleotide and oligomer molecules for expressing a human phenylalanine hydroxylase (PAH), or a fragment thereof having PAH activity. The polynucleotide and oligomer molecules are expressible to provide the human PAH or a fragment thereof having PAH activity. The molecules can be used as active agents to express an active polypeptide or protein in cells or subjects. The agents can be used in methods for ameliorating, preventing, delaying onset, or treating a disease or condition associated with phenylketonuria, decreased metabolism of phenylalanine, or increased levels of phenylalanine in a subject.