The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2024
Filed:
May. 09, 2022
The Secant Group, Llc, Telford, PA (US);
Stephanie Reed, Conshohocken, PA (US);
Carissa Smoot, Harleysville, PA (US);
Dennis Shull, Phoenixville, PA (US);
Todd Crumbling, Perkasie, PA (US);
John D'Ottavio, Telford, PA (US);
Peter D. Gabriele, Frisco, TX (US);
Jeremy J. Harris, Doylestown, PA (US);
Charles Brendan Nicholson, Coopersburg, PA (US);
Jared Ely, Quakertown, PA (US);
THE SECANT GROUP, LLC, Telford, PA (US);
Abstract
A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.