The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2024
Filed:
Nov. 05, 2018
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
The Research Foundation for the State University of New York, Amherst, NY (US);
Katelyn Arnold, Chapel Hill, NC (US);
Ding Xu, East Amherst, NY (US);
Yongmei Xu, Durham, NC (US);
Rafal Pawlinski, Chapel Hill, NC (US);
Jian Liu, Chapel Hill, NC (US);
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
The Research Foundation for the State University of New York, Amherst, NY (US);
Abstract
Provided herein are small molecule compounds, including non-anticoagulant heparan sulfate oligosaccharide molecules, having anti-inflammatory properties and capable of interacting with high mobility group box 1 (HMGB1) proteins in a manner sufficient to affect an interaction between the HMGB1 protein and a receptor for advanced glycation end products (RAGE). Also provided herein are methods of treating Paracetamol (APAP) overdose in subjects.