The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2023
Filed:
Mar. 17, 2020
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Marine Prissette, Brooklyn, NY (US);
Matthew Koss, Pleasantville, NY (US);
Wen Fury, New York, NY (US);
Brian Zambrowicz, Sleepy Hollow, NY (US);
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12N 5/00 (2006.01); C12N 5/071 (2010.01); C12N 9/22 (2006.01); C12N 15/113 (2010.01); G01N 21/64 (2006.01); G16B 25/00 (2019.01); A61K 48/00 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1082 (2013.01); C12N 5/0018 (2013.01); C12N 5/0686 (2013.01); C12N 9/22 (2013.01); C12N 15/1086 (2013.01); C12N 15/1089 (2013.01); C12N 15/113 (2013.01); G01N 21/6428 (2013.01); G01N 33/6896 (2013.01); G16B 25/00 (2019.02); A61K 48/00 (2013.01); C12N 2310/20 (2017.05); C12N 2320/12 (2013.01); C12N 2502/99 (2013.01); C12N 2800/80 (2013.01); G01N 2021/6441 (2013.01); G01N 2800/7047 (2013.01);
Abstract
Cas-protein-ready tau biosensor cells, CRISPR/Cas synergistic activation mediator (SAM)-ready tau biosensor cells, and methods of making and using such cells to screen for genetic modifiers of tau seeding or aggregation are provided. Reagents and methods for sensitizing such cells to tau seeding activity or tau aggregation or for causing tau aggregation are also provided.