The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2023
Filed:
Oct. 02, 2020
Nektar Therapeutics, San Francisco, CA (US);
Antoni Kozlowski, Huntsville, AL (US);
Samuel P. McManus, Huntsville, AL (US);
Sachin Tipnis, Houston, TX (US);
Greg Lavaty, Sugar Land, TX (US);
David Swallow, Spring, TX (US);
John R. Handley, Eveleth, MN (US);
Anthony G. Schaefer, Huntsville, AL (US);
Nektar Therapeutics, San Francisco, CA (US);
Abstract
Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.