The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2023
Filed:
Feb. 11, 2019
Applicant:
Hadasit Medical Research Services & Development Ltd., Jerusalem, IL;
Inventors:
Assignee:
HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD., Jerusalem, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C12N 5/0783 (2010.01); A61K 38/17 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70503 (2013.01); A61K 39/001111 (2018.08); A61P 35/00 (2018.01); A61K 2039/5152 (2013.01); A61K 2039/575 (2013.01); C07K 2319/02 (2013.01);
Abstract
The invention relates to cancer immunotherapy, particularly to improved therapeutic modalities involving specifically modulating the expression and/or activity of SLAMF6 splice variants. More specifically, embodiments of the invention provide compositions and methods for cancer therapy, including adoptive T cell transfer therapies, cell vaccines and/or polypeptide- based medicaments. In various embodiments, compositions and methods providing selective augmentation of SLAMF6 variant 3 (SLAMF6) N expression or activity on T cells and/or tumor cells are provided.