The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 05, 2023

Filed:

Sep. 12, 2018
Applicant:

Agency for Science, Technology and Research, Singapore, SG;

Inventors:

Soo Yei Ho, Singapore, SG;

Anders Poulsen, Singapore, SG;

Sum Wai Eldwin Tan, Singapore, SG;

Shi Hua Ang, Singapore, SG;

Thomas Hugo Keller, Singapore, SG;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 231/12 (2006.01); C07D 233/12 (2006.01); C07D 249/08 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); A61P 35/00 (2006.01); C07D 233/06 (2006.01); C07D 233/60 (2006.01); C07D 261/08 (2006.01); C07D 277/24 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61P 35/00 (2018.01); C07D 231/12 (2013.01); C07D 233/06 (2013.01); C07D 233/60 (2013.01); C07D 249/08 (2013.01); C07D 261/08 (2013.01); C07D 277/24 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01);
Abstract

The present invention relates to compounds of general Formula (I), and/or tautomers, enantiomers, solvates, hydrates, and pharmaceutically acceptable salts thereof. The present invention also relates to compounds of Formula (I) for use in therapy, methods of treating isoprenylcysteine carboxyl methyltransferase (ICMT) related disorders or uses of compounds of Formula (I) in the manufacture of a medicament for the treatment of ICMT-related disorders, wherein the disorder is cancer and/or progeria. The present invention further relates to processes for synthesizing compounds of Formula (I).


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