The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2023
Filed:
Mar. 13, 2020
Macrogenics, Inc., Rockville, MD (US);
Leslie S. Johnson, Rockville, MD (US);
Ling Huang, Rockville, MD (US);
Gurunadh Reddy Chichili, Rockville, MD (US);
Kalpana Shah, Rockville, MD (US);
Chia-Ying Kao Lam, Rockville, MD (US);
Stephen James Burke, Rockville, MD (US);
Liqin Liu, Rockville, MD (US);
Paul A. Moore, Rockville, MD (US);
Ezio Bonvini, Rockville, MD (US);
Bhaswati Barat, Rockville, MD (US);
MACROGENICS, INC., Rockville, MD (US);
Abstract
The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Binding Domains may be selected such that the Tri-Specific Binding Molecules are capable of binding to any three different epitopes. Such epitopes may be epitopes of the same antigen or epitopes of two or three different antigens. In a preferred embodiment, one of such epitopes will be capable of binding to CD3, the second of such epitopes will be capable of binding to CD8, and the third of such epitopes will be capable of binding to an epitope of a Disease-Associated Antigen. The invention also provides a novel ROR1-binding antibody, as well as derivatives thereof and uses for such compositions.