The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2023
Filed:
Dec. 20, 2021
Protalix Ltd., Carmiel, IL;
Lilach Chen Zeltsburg, Nahariya, IL;
Ilya Ruderfer, Carmiel, IL;
Avidor Shulman, Rakefet, IL;
Liat Fux, Kiryat-Motzkin, IL;
Yulia Ugortsev, Nesher, IL;
Hagit Neta, Haifa, IL;
Sivan Gelley, Kfar-Saba, IL;
Elad Lavee Laviad, Kfar Neter, IL;
Yoseph Shaaltiel, Timrat, IL;
Protalix Ltd., Carmiel, IL;
Abstract
Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I protein. Processes of preparing the modified DNase I protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided.